| IKATI # | Igama Lomkhiqizo | Incazelo |
| I-CPD100616 | Emricasan | I-Emricasan, eyaziwa nangokuthi i-IDN 6556 kanye ne-PF 03491390, iyi-inhibitor ye-caspase esezingeni lokuqala ekuhlolweni kwemitholampilo yokwelashwa kwezifo zesibindi. I-Emricasan (IDN-6556) inciphisa ukulimala kwesibindi kanye ne-fibrosis kumodeli ye-murine ye-non-alcohol steatohepatitis. I-IDN6556 isiza ukufakwa kweziqhingi eziseceleni kumodeli ye-porcine islet autotransplant. I-IDN-6556 yomlomo ingase yehlise umsebenzi we-aminotransferase ezigulini ezine-hepatitis C engapheli. I-PF-03491390 elawulwa ngomlomo igcinwe esibindi isikhathi eside ngokuchayeka okuphansi kwesistimu, okwenza umphumela we-hepatoprotective ngokumelene nokulimala kwesibindi kwe-alpha-fas kumodeli yegundane. . |
| I-CPD100615 | Q-VD-Oph | I-QVD-OPH, eyaziwa nangokuthi i-Quinoline-Val-Asp-Difluorophenoxymethylketone, iyi-spectrum ebanzi ye-caspase inhibitor enezici ezinamandla zokulwa ne-apoptotic. I-Q-VD-OPh ivimbela ukushaywa kwengane esanda kuzalwa ku-P7 rat: indima yobulili. I-Q-VD-OPh inemiphumela elwa ne-leukemia futhi ingasebenzisana nama-analogi ka-vitamin D ukuze kwandiswe ukusayinda kwe-HPK1 kumaseli e-AML. I-Q-VD-OPh inciphisa i-apoptosis ebangelwa ukuhlukumezeka futhi ithuthukise ukutholakala kokusebenza kwesitho sangemuva kumagundane ngemva kokulimala komgogodla. |
| I-CPD100614 | Z-DEVD-FMK | I-Z-DEVD-fmk iyi-cell-permeable, inhibitor engabuyiseleki emuva ye-caspase-3. I-Caspase-3 iyi-cysteineyl aspartate-specific protease edlala indima ebalulekile ku-apoptosis. |
| I-CPD100613 | Z-IETD-FMK | I-MDK4982, eyaziwa nangokuthi i-Z-IETD-FMK, iyisivimbeli esinamandla, esikwaziyo ukungena kuseli, esingahlehliseki emuva se-caspase-8 kanye ne-granzyme B., i-Caspase-8 Inhibitor II ilawula umsebenzi webhayoloji we-Caspase-8. I-MDK4982 ivimbela ngempumelelo i-apoptosis ebangelwa igciwane lomkhuhlane kumaseli e-HeLa. I-MDK4982 iphinde ivimbele i-granzyme B. I-MDK4982 ine-CAS#210344-98-2. |
| I-CPD100612 | Z-VAD-FMK | I-Z-VAD-FMK iyi-cell-permeable, i-pan-caspase inhibitor engabuyiseleki emuva. I-Z-VAD-FMK ivimbela ukucutshungulwa kwe-caspase kanye nokungeniswa kwe-apoptosis kumaseli wesimila ku-vitro (IC50 = 0.0015 - 5.8 mM). |
| I-CPD100611 | I-Belnacasan | I-Belnacasan, eyaziwa nangokuthi i-VX-765, yakhelwe ukuvimbela i-Caspase, okuyi-enzyme elawula ukukhiqizwa kwama-cytokines amabili, i-IL-1b ne-IL-18. I-VX-765 ikhonjiswe ukuthi ivimbela ukuquleka okunamandla kumamodeli angaphambi komtholampilo. Ngaphezu kwalokho, i-VX-765 ibonise umsebenzi kumamodeli we-preclinical wesithuthwane esingamahlalakhona. I-VX-765 yayinikwe umthamo ezigulini ezingaphezu kwe-100 ezivivinyweni zomtholampilo zesigaba-I kanye nesigaba-IIa eziphathelene nezinye izifo, kuhlanganise nokuhlolwa komtholampilo kwesigaba-IIa sezinsuku ezingama-28 ezigulini ezine-psoriasis. Iqede isigaba sokwelashwa se-phase-IIa yokuhlolwa komtholampilo kwe-VX-765 ebhalise cishe iziguli ezingama-75 ezinesithuthwane esingazweli ekwelashweni. Isilingo somtholampilo esingaboni kabili, esingahleliwe, esilawulwa yi-placebo saklanyelwe ukuhlola ukuphepha, ukubekezelelana kanye nomsebenzi womtholampilo we-VX-765. |
