| CAT # | Khoom npe | Kev piav qhia |
| PIB 100616 | Emricasan | Emricasan, tseem hu ua IDN 6556 thiab PF 03491390, yog thawj-hauv-chav caspase inhibitor hauv kev sim tshuaj rau kev kho mob siab. Emricasan (IDN-6556) txo lub siab raug mob thiab fibrosis nyob rau hauv ib tug murine qauv ntawm non-alcoholic steatohepatitis. IDN6556 ua kom yooj yim marginal loj islet engraftment nyob rau hauv ib tug porcine islet autotransplant qauv. Qhov ncauj IDN-6556 tuaj yeem txo qis aminotransferase kev ua haujlwm hauv cov neeg mob uas muaj kab mob siab C. Orally-administered PF-03491390 yog khaws cia hauv daim siab rau lub sijhawm ntev nrog kev ua haujlwm tsis zoo, ua rau muaj kev tiv thaiv hepatoprotective tiv thaiv alpha-fas-induced daim siab raug mob hauv tus qauv nas. . |
| PIB 100615 | Q-VD-Oph | QVD-OPH, tseem hu ua Quinoline-Val-Asp-Difluorophenoxymethylketone, yog ib qho broad spectrum caspase inhibitor nrog muaj zog antiapoptotic zog. Q-VD-OPh tiv thaiv kev mob stroke hauv menyuam yaus hauv P7 nas: lub luag haujlwm rau poj niam txiv neej. Q-VD-OPh muaj kev tiv thaiv kab mob leukemia thiab tuaj yeem cuam tshuam nrog cov tshuaj vitamin D kom nce HPK1 signaling hauv AML hlwb. Q-VD-OPh txo cov kev raug mob vim raug apoptosis thiab txhim kho kev rov qab los ntawm hind-limb muaj nuj nqi hauv cov nas tom qab raug mob qaum. |
| PIB 100614 | Z-DEVD-FMK | Z-DEVD-fmk yog cell-permeable, irreversible inhibitor ntawm caspase-3. Caspase-3 yog cysteyl aspartate-specific protease uas ua lub luag haujlwm tseem ceeb hauv apoptosis. |
| PIB 100613 | Z-IETD-FMK | MDK4982, tseem hu ua Z-IETD-FMK, yog ib qho muaj zog, cell-permeable, irreversible inhibitor ntawm caspase-8 thiab granzyme B., Caspase-8 Inhibitor II tswj cov kev ua si lom neeg ntawm Caspase-8. MDK4982 muaj txiaj ntsig zoo inhibits tus kab mob khaub thuas-induced apoptosis hauv HeLa hlwb. MDK4982 kuj inhibits granzyme B. MDK4982 muaj CAS#210344-98-2. |
| PIB 100612 | Z-VAD-FMK | Z-VAD-FMK yog cell-permeable, irreversible pan-caspase inhibitor. Z-VAD-FMK inhibits caspase ua thiab apoptosis induction hauv qog hlwb hauv vitro (IC50 = 0.0015 - 5.8 mM). |
| PIB 100611 | Belnacasan | Belnacasan, tseem hu ua VX-765, yog tsim los inhibit Caspase, uas yog ib qho enzyme uas tswj cov tiam ntawm ob cytokines, IL-1b thiab IL-18. VX-765 tau pom tias inhibit mob qaug dab peg hauv cov qauv ua ntej. Tsis tas li ntawd, VX-765 tau qhia txog kev ua haujlwm hauv preclinical qauv ntawm kev mob vwm. VX-765 tau muab tshuaj rau ntau tshaj 100 tus neeg mob nyob rau theem-I thiab theem-IIa kev sim tshuaj ntsuam xyuas ntsig txog lwm yam kab mob, suav nrog 28-hnub theem-IIa kev sim tshuaj rau cov neeg mob psoriasis. Nws tau ua tiav cov theem kev kho mob ntawm theem-IIa kev sim tshuaj ntsuam xyuas ntawm VX-765 uas tau tso npe kwv yees li 75 tus neeg mob uas muaj kev tiv thaiv kab mob vwm. Qhov ob-dig muag, randomized, cov tshuaj placebo-tswj tshuaj ntsuam xyuas tau tsim los ntsuas kev nyab xeeb, kev ua siab ntev thiab kev kho mob ntawm VX-765. |
