| PUSI # | Igoa Oloa | Fa'amatalaga |
| CPD100616 | Emricasan | Emricasan, e lauiloa foi o le IDN 6556 ma le PF 03491390, o se fa'atosina caspase muamua-i-vasega i faʻataʻitaʻiga faʻapitoa mo togafitiga o faʻamaʻi ate. Emricasan (IDN-6556) faʻaitiitia le manua o le ate ma le fibrosis i se faʻataʻitaʻiga murine ole steatohepatitis e le o le ava malosi. IDN6556 fa'afaigofieina le fa'apipi'iina o tama'i motu tele i se fa'ata'ita'iga autotransplant tama'i puaa. Oral IDN-6556 e mafai ona faʻaitiitia ai le gaioiga aminotransferase i tagata mamaʻi e maua i le hepatitis C. O le tuʻuina atu o le PF-03491390 o loʻo taofia i totonu o le ate mo taimi uumi ma le maualalo o le faʻaogaina o le tino, faʻaaogaina se aafiaga hepatoprotective e faasaga i manuʻa ate alpha-fas i se faʻataʻitaʻiga isumu. . |
| CPD100615 | Q-VD-Oph | QVD-OPH, e taʻua foi o Quinoline-Val-Asp-Difluorophenoxymethylketone, o se faʻalavelave faʻapipiʻi caspase lautele faʻatasi ai ma mea malosi antiapoptotic. Q-VD-OPh e puipuia le ta'i o pepe pepe ile iole P7: ose matafaioi mo itupa. O le Q-VD-OPh e iai a'afiaga o le leukemia ma e mafai ona fegalegaleai ma vaitamini D analogs e fa'ateleina ai le fa'ailoga HPK1 i sela AML. Q-VD-OPh e faʻaitiitia ai le apoptosis faʻaleagaina ma faʻaleleia le toe faʻaleleia o le faʻaogaina o lima i isumu pe a maeʻa manua o le vaʻa. |
| CPD100614 | Z-DEVD-FMK | O le Z-DEVD-fmk o se masini e mafai ona faʻaogaina, e le mafai ona faʻaaogaina o le caspase-3. Caspase-3 o le cysteinyl aspartate-specific protease lea e faia se sao tutotonu i apoptosis. |
| CPD100613 | Z-IETD-FMK | MDK4982, lea e taʻua foi o le Z-IETD-FMK, o se mea malosi, cell-permeable, le mafai ona toe faʻafoʻiina o le caspase-8 ma le granzyme B., O le Caspase-8 Inhibitor II e pulea le gaioiga o meaola o Caspase-8. O le MDK4982 e taofia lelei le apoptosis e mafua mai i le siama i totonu o sela HeLa. MDK4982 fa'agata fo'i le granzyme B. MDK4982 iai CAS#210344-98-2. |
| CPD100612 | Z-VAD-FMK | O le Z-VAD-FMK o se masini e mafai ona faʻaogaina, e le mafai ona faʻaaogaina pan-caspase inhibitor. O le Z-VAD-FMK e taofia ai le faʻaogaina o le caspase ma le faʻaogaina o le apoptosis i sela tumo i vitro (IC50 = 0.0015 - 5.8 mM). |
| CPD100611 | Belnacasan | Belnacasan, lea e lauiloa foi o le VX-765, ua mamanuina e taofia Caspase, o se enzyme e pulea le gaosiga o lua cytokines, IL-1b ma IL-18. VX-765 ua faʻaalia e taofiofia le faoa faamalosi i faʻataʻitaʻiga faʻapitoa. E le gata i lea, VX-765 ua faʻaalia le gaioiga i faʻataʻitaʻiga faʻapitoa o le epilepsy masani. VX-765 na fa'aigoaina i le silia ma le 100 tagata gasegase i le vaega-I ma le vaega-IIa fa'ata'ita'iga fa'apitoa e feso'ota'i ma isi fa'ama'i, e aofia ai le 28-aso fa'ata'ita'iga-IIa fa'ata'ita'iga i tagata mama'i ma le psoriasis. Ua maeʻa le vaega o togafitiga o se vaega-IIa faʻataʻitaʻiga o le VX-765 lea na lesitalaina pe tusa ma le 75 tagata mamaʻi e maua i togafitiga epilepsy. O le faʻataʻitaʻiga faʻataʻitaʻi lua-tauaso, faʻafuaseʻi, placebo-pulea faʻataʻitaʻiga faʻataʻitaʻiga na fuafuaina e iloilo ai le saogalemu, faʻamalieina ma le gaioiga o le VX-765. |
