| KATSE # | Lebitso la Sehlahiswa | Tlhaloso |
| CPD100616 | Emricasan | Emricasan, eo hape e tsejoang e le IDN 6556 le PF 03491390, ke "caspase inhibitor" ea pele-pele litekong tsa meriana bakeng sa phekolo ea mafu a sebete. Emricasan (IDN-6556) e fokotsa kotsi ea sebete le fibrosis ka mohlala oa murine oa steatohepatitis e seng joala. IDN6556 e thusa ho kenngoa ha lihlekehleke tse ka thōko ho mofuta oa porcine islet autotransplant. IDN-6556 ea molomo e ka fokotsa ts'ebetso ea aminotransferase ho bakuli ba nang le lefu la sebete le sa foleng la lefu la sebete la C. PF-03491390 e tsamaisoang ka molomo e bolokiloe sebeteng ka nako e telele e nang le ts'oaetso e tlaase ea tsamaiso, e nang le phello ea hepatoprotective khahlanong le kotsi ea sebete e bakoang ke alpha-fas ka mohlala oa mouse. . |
| CPD100615 | Q-VD-Oph | QVD-OPH, eo hape e tsejoang e le Quinoline-Val-Asp-Difluorophenoxymethylketone, ke sephara se sephara sa caspase inhibitor se nang le thepa e matla ea antiapoptotic. Q-VD-OPh e thibela ho otloa ke neonatal ho P7 rat: karolo ea bong. Q-VD-OPh e na le liphello tse khahlanong le leukemia 'me e ka sebelisana le li-analogue tsa vithamine D ho eketsa pontšo ea HPK1 liseleng tsa AML. Q-VD-OPh e fokotsa apoptosis e bakoang ke ho sithabela maikutlo 'me e ntlafatsa ho hlaphoheloa ha setho sa morao-rao ho likhoto ka mor'a kotsi ea mokokotlo. |
| CPD100614 | Z-DEVD-FMK | Z-DEVD-fmk ke cell-permeable, inhibitor e ke keng ea fetoloa ea caspase-3. Caspase-3 ke cysteineyl aspartate-specific protease e bapalang karolo ea mantlha ho apoptosis. |
| CPD100613 | Z-IETD-FMK | MDK4982, e tsejoang hape e le Z-IETD-FMK, ke inhibitor e matla, e khonang ho kenella ka liseleng, e ke keng ea fetoloa ea caspase-8 le granzyme B., The Caspase-8 Inhibitor II e laola ts'ebetso ea tlhaho ea Caspase-8. MDK4982 e thibela ka katleho apoptosis e bakoang ke kokoana-hloko ea ntaramane liseleng tsa HeLa. MDK4982 e boetse e thibela granzyme B. MDK4982 e na le CAS #210344-98-2. |
| CPD100612 | Z-VAD-FMK | Z-VAD-FMK ke cell-permeable, e ke keng ea fetoloa ea pan-caspase inhibitor. Z-VAD-FMK e thibela ts'ebetso ea caspase le ho kenngoa ha apoptosis liseleng tsa tumor in vitro (IC50 = 0.0015 - 5.8 mM). |
| CPD100611 | Belnacasan | Belnacasan, e tsejoang hape e le VX-765, e etselitsoe ho thibela Caspase, e leng enzyme e laolang tlhahiso ea li-cytokine tse peli, IL-1b le IL-18. VX-765 e bonts'itsoe hore e thibela ho ts'oaroa ho matla mefuteng ea preclinical. Ntle le moo, VX-765 e bonts'itse ts'ebetso mefuteng ea pele ea lefu la sethoathoa se sa foleng. VX-765 e ne e fuoe bakuli ba fetang 100 litekong tsa kliniki tsa phase-I le phase-IIa tse amanang le mafu a mang, ho kenyeletsoa le teko ea kliniki ea matsatsi a 28 ho bakuli ba nang le psoriasis. E phethetse mohato oa phekolo oa teko ea kliniki ea phase-IIa ea VX-765 e ngolisitseng bakuli ba ka bang 75 ba nang le lefu la sethoathoa le hananang le phekolo. Teko ea kliniki e laoloang ka makhetlo a mabeli, e sa tloaelehang, e laoloang ke placebo e ne e etselitsoe ho hlahloba ts'ireletso, mamello le ts'ebetso ea bongaka ea VX-765. |
