ART558

Chemical Name:

(2S,3R)-1-(3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl)-3-hydroxy-N-methyl-N-(m-tolyl)pyrrolidine-2-carboxamide

SMILES Code: 

O=C([C@H]1N(C2=NC(C)=CC(C(F)(F)F)=C2C#N)CC[C@H]1O)N(C)C3=CC=CC(C)=C3

InChi Code:

InChI=1S/C21H21F3N4O2/c1-12-5-4-6-14(9-12)27(3)20(30)18-17(29)7-8-28(18)19-15(11-25)16(21(22,23)24)10-13(2)26-19/h4-6,9-10,17-18,29H,7-8H2,1-3H3/t17-,18+/m1/s1

InChi Key:

YHMDHAMZFMNMTF-MSOLQXFVSA-N

Keyword:

2603528-97-6；CAS:2603528-97-6；CAS：2603528-97-6；ART558；ART 558；ART-558

Solubility: 

Storage: 

Description: 

Art558 is a nanomolar, efficient, selective, low molecular weight, allosteric DNA polymerase pol θ Inhibitor (ic50=7.9 nm). Art558 can be used in cancer research.

Target: Pol of allosteric DNA polymerase activity θ Inhibitor (ic50=7.9 nm)