2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile
For scientific research only, not for patients.
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Chemical Name:
4-((1r,3r)-3-amino-2,2,4,4-tetramethylcyclobutoxy)-2-chlorobenzonitrile
SMILES Code:
N#CC1C(Cl)=CC(O[C@@H]2C(C)(C)[C@@H](N)C2(C)C)=CC=1
InChi Code:
InChI=1S/C15H19ClN2O/c1-14(2)12(18)15(3,4)13(14)19-10-6-5-9(8-17)11(16)7-10/h5-7,12-13H,18H2,1-4H3/t12-,13-
InChi Key:
ZMQAQKRIAFCCDB-JOCQHMNTSA-N
Keyword:
1818885-54-9；CAS:1818885-54-9；CAS：1818885-54-9
Solubility:
Storage:
Description:
Ar agonist 1 (compound 29) is an effective ar antagonist, which binds to E3 ligase ligand and has weak binding affinity with VHL protein. It is used to synthesize protac ard-266 (hy-133020).
Target: An effective ar antagonist for the synthesis of protac ard-266
