| CAT # | Ingoa Hua | Whakaahuatanga |
| CPD100616 | Emricasan | Ko Emricasan, e mohiotia ana ko te IDN 6556 me te PF 03491390, he kaiwawao caspase tuatahi i roto i te akomanga i roto i nga whakamatautau haumanu mo te maimoatanga o nga mate ate. Ko te Emricasan (IDN-6556) ka whakaheke i te whara ate me te fibrosis i roto i te tauira murine o te steatohepatitis kore-waipiro. Ko te IDN6556 e whakahaere ana i te whakairo o te motu papatipu tawhē i roto i te tauira whakawhiti aunoa o te motu porcine. Ka taea e Oral IDN-6556 te whakaheke i te mahi aminotransferase i roto i nga turoro me te mate hepatitis C. Ko te PF-03491390 te whakahaere-waha ka mau ki roto i te ate mo nga wa roa me te iti o te whakamaanga o te punaha, ka tukuna he paanga hepatoprotective ki te whara ate alpha-fas i roto i te tauira kiore . |
| CPD100615 | Q-VD-Oph | Ko te QVD-OPH, e mohiotia ana ko Quinoline-Val-Asp-Difluorophenoxymethylketone, he aukati caspase whanui whanui me nga taonga antiapoptotic kaha. Ko te Q-VD-OPh te aukati i te whiu whanau hou i roto i te kiore P7: he mahi mo te ira tangata. Kei a Q-VD-OPh nga paanga anti-reukemia, ka taea e ia te taunekeneke me nga tairitenga huaora D hei whakanui ake i te tohu HPK1 i roto i nga pūtau AML. Ko te Q-VD-OPh he whakaheke i te apoptosis i puta mai i te whara me te whakapai ake i te whakaora o te mahi hid-limm i roto i nga kiore i muri i te whara o te taurakira. |
| CPD100614 | Z-DEVD-FMK | Ko te Z-DEVD-fmk he pūtau-permeable, aukati korekore o te caspase-3. Ko te Caspase-3 he protease motuhake-a-cysteinyl aspartate e whai waahi nui ana ki te apoptosis. |
| CPD100613 | Z-IETD-FMK | Ko te MDK4982, e mohiotia ana ko Z-IETD-FMK, he kaha, he pukoro-permeable, he aukati korekore o te caspase-8 me te granzyme B., Ko te Caspase-8 Inhibitor II te whakahaere i te mahi koiora o Caspase-8. Ko te MDK4982 ka taea te aukati i te apoptosis a te huaketo rewharewha i roto i nga pūtau HeLa. Ko te MDK4982 he aukati i te granzyme B. Kei a MDK4982 he CAS#210344-98-2. |
| CPD100612 | Z-VAD-FMK | Ko te Z-VAD-FMK he pūtau-permeable, he aukati pan-caspase e kore e taea te huri. Ko te Z-VAD-FMK ka whakakore i te tukatuka caspase me te whakauru apoptosis i roto i nga pukupuku pukupuku i roto i te vitro (IC50 = 0.0015 - 5.8 mM). |
| CPD100611 | Peretana | Ko Belnacasan, e mohiotia ana ko VX-765, i hangaia hei aukati i te Caspase, he enzyme e whakahaere ana i te whakatipuranga o nga cytokines e rua, IL-1b me IL-18. Kua whakaatuhia te VX-765 ki te aukati i nga hopukanga whakapeka i roto i nga tauira preclinical. I tua atu, kua whakaatu a VX-765 i nga mahi i roto i nga tauira o mua o te mate pukupuku tawhito. Ko te VX-765 i werohia ki runga i te 100 nga turoro i te wahanga-I me te wahanga-IIa nga whakamatautau haumanu e pa ana ki etahi atu mate, tae atu ki te whakamatautau haumanu 28-ra-IIa i nga turoro me te psoriasis. Kua oti i a ia te waahi maimoatanga o te wahanga-IIa whakamatautau haumanu o VX-765 i whakauru atu ki te 75 nga turoro me te mate rewharewha-atete. Ko te whakamatautau haumanu mata-rua, matapōkeretia, e whakahaerehia ana e te placebo hei arotake i te haumarutanga, te pai me te mahi haumanu o VX-765. |
