| nwamba # | Aha ngwaahịa | Nkọwa |
| CPD100616 | Emricasan | Emricasan, nke a makwaara dị ka IDN 6556 na PF 03491390, bụ ihe mgbochi caspase nke mbụ na klaasị na nnwale ụlọ ọgwụ maka ọgwụgwọ ọrịa imeju. Emricasan (IDN-6556) na-ebelata mmerụ imeju na fibrosis na ụdị murine nke steatohepatitis na-abụghị mmanya. IDN6556 na-eme ka mkpirisi akuku agwaetiti dị n'akụkụ n'ime ihe nlere transplant nke agwaetiti porcine. Oral IDN-6556 nwere ike belata ọrụ aminotransferase na ndị ọrịa nwere ịba ọcha n'anya C na-adịghị ala ala. A na-ejigide PF-03491390 nke ọnụ ọnụ na imeju ruo ogologo oge na mkpughe sistemu dị ala, na-egosipụta mmetụta hepatoprotective megide mmerụ imeju nke alfa-fas na ụdị òké. . |
| CPD100615 | Q-VD-Oph | QVD-OPH, nke a makwaara dị ka Quinoline-Val-Asp-Difluorophenoxymethylketone, bụ ihe mgbochi caspase sara mbara nke nwere ikike antiapoptotic dị ike. Q-VD-OPh na-egbochi ọrịa strok nwa ọhụrụ na oke P7: ọrụ maka okike. Q-VD-OPh nwere mmetụta mgbochi ọrịa leukemia ma nwee ike ịmekọrịta na vitamin D analogs iji mee ka akara HPK1 dị na sel AML. Q-VD-OPh na-ebelata apoptosis nke na-akpata trauma ma na-eme ka mgbake nke ọrụ azụ azụ n'ime oke mgbe mmerụ ahụ gasịrị. |
| CPD100614 | Z-DEVD-FMK | Z-DEVD-fmk bụ cell-permeable, onye na-emechi ihe na-adịghị agbanwe agbanwe nke caspase-3. Caspase-3 bụ cysteinyl aspartate-kpọmkwem protease nke na-arụ ọrụ etiti na apoptosis. |
| CPD100613 | Z-IETD-FMK | MDK4982, nke a makwaara dị ka Z-IETD-FMK, bụ onye nwere ike, cell-permeable, onye na-emechi ihe na-adịghị agbanwe agbanwe nke caspase-8 na granzyme B., Caspase-8 Inhibitor II na-achịkwa ọrụ ndu nke Caspase-8. MDK4982 na-egbochi apoptosis nje butere influenza nke ọma na sel HeLa. MDK4982 na-egbochikwa granzyme B. MDK4982 nwere CAS # 210344-98-2. |
| CPD100612 | Z-VAD-FMK | Z-VAD-FMK bụ cell-permeable, onye na-egbochi pan-caspase na-apụghị ịgbagha agbagha. Z-VAD-FMK na-egbochi nhazi caspase na ntinye apoptosis na cell tumor in vitro (IC50 = 0.0015 - 5.8 mM). |
| CPD100611 | Belnacasan | Belnacasan, nke a makwaara dị ka VX-765, ka emebere iji gbochie Caspase, nke bụ enzyme nke na-achịkwa ọgbọ nke cytokines abụọ, IL-1b na IL-18. E gosiputara VX-765 ka ọ gbochie oke ọdịdọ n'ụdị preclinical. Na mgbakwunye, VX-765 egosila ọrụ na ụdị preclinical nke Akwụkwụ na-adịghị ala ala. Ejirila VX-765 n'ime ndị ọrịa 100 n'ime oge-I na nke IIa ule ụlọ ọgwụ metụtara ọrịa ndị ọzọ, gụnyere nnwale ụlọ ọgwụ ụbọchị 28-IIa na ndị ọrịa nwere psoriasis. O mechaala usoro ọgwụgwọ nke usoro-IIa ụlọ ọgwụ nke VX-765 nke debanyere aha ihe dị ka ndị ọrịa 75 nwere akwụkwụ na-eguzogide ọgwụgwọ. Emebere nnwale ụlọ ọgwụ a na-achịkwa okpukpu abụọ, kpuru ìsì, nke a na-achịkwaghị achịkwa iji nyochaa nchekwa, nnabata na ọrụ ụlọ ọgwụ nke VX-765. |
