| CAT # | Product Name | Tsanangudzo |
| CPD100616 | Emricasan | Emricasan, inozivikanwawo seIDN 6556 uye PF 03491390, ndiyo yekutanga-in-class caspase inhibitor mumakiriniki ekuedzwa kwekurapa kwezvirwere zvechiropa. Emricasan (IDN-6556) inoderedza kukuvara kwechiropa uye fibrosis mumurine modhi yeasiri doro steatohepatitis. IDN6556 inogonesa marginal mass islet engraftment mune porcine islet autotransplant modhi. Oral IDN-6556 inogona kuderedza basa reaminotransferase kune varwere vane chirwere chisingaperi chehepatitis C. Inoshandiswa nemuromo-PF-03491390 inochengetwa muchiropa kwenguva yakareba ine yakaderera systemic exposure, ichiita hepatoprotective effect kurwisa alpha-fas-induced chiropa kukuvara mumuenzaniso wembeva. . |
| CPD100615 | Q-VD-Oph | QVD-OPH, inozivikanwawo seQuinoline-Val-Asp-Difluorophenoxymethylketone, yakafara spectrum caspase inhibitor ine simba antiapoptotic properties. Q-VD-OPh inodzivirira neonatal sitiroko muP7 rat: basa revakadzi. Q-VD-OPh ine anti-leukemia mhedzisiro uye inogona kudyidzana nevhitamini D analogs kuwedzera HPK1 kusaina mumaseru AML. Q-VD-OPh inoderedza kushungurudzika-induced apoptosis uye inovandudza kudzoreredza kwemashure-enhengo basa mumakonzo mushure mekukuvara kwemusana. |
| CPD100614 | Z-DEVD-FMK | Z-DEVD-fmk is cell-permeable, irreversible inhibitor ye caspase-3. Caspase-3 inonzi cysteineyl aspartate-specific protease inoita basa guru muapoptosis. |
| CPD100613 | Z-IETD-FMK | MDK4982, inozivikanwawo seZ-IETD-FMK, ine simba, cell-permeable, irreversible inhibitor ye caspase-8 uye granzyme B., The Caspase-8 Inhibitor II inodzora biological chiitiko cheCaspase-8. MDK4982 inonyatso inhibits influenza virus-induced apoptosis mumasero eHeLa. MDK4982 zvakare inhibits granzyme B. MDK4982 ine CAS#210344-98-2. |
| CPD100612 | Z-VAD-FMK | Z-VAD-FMK is cell-permeable, irreversible pan-caspase inhibitor. Z-VAD-FMK inhibits caspase processing uye apoptosis induction mu tumor cell in vitro (IC50 = 0.0015 - 5.8 mM). |
| CPD100611 | Belnacasan | Belnacasan, inozivikanwawo seVX-765, yakagadzirirwa kuvharidzira Caspase, iri enzyme inodzora chizvarwa chema cytokines maviri, IL-1b uye IL-18. VX-765 yakaratidzwa kuti inhibit acute seizures mu preclinical modhi. Uye zvakare, VX-765 yakaratidza chiitiko mu preclinical modhi yechirwere chepfari. VX-765 yakanga yaiswa muvarwere vanopfuura 100 muchikamu-I uye chikamu-IIa miedzo yemakiriniki ine chokuita nezvimwe zvirwere, kusanganisira 28-day phase-IIa kliniki yekuedza kune varwere vane psoriasis. Yakapedza chikamu chekurapa chechikamu-IIa kliniki yekuedza yeVX-765 iyo yakanyora vangangoita 75 varwere vane kurapa-inodzivirira pfari. Iyo yakapetwa kaviri-mapofu, randomized, placebo-inodzorwa kliniki yekuedza yakagadzirirwa kuongorora kuchengeteka, kushivirira uye kliniki chiitiko cheVX-765. |
