| MPAKA # | Dzina lazogulitsa | Kufotokozera |
| Chithunzi cha CPD100616 | Emricasan | Emricasan, yemwe amadziwikanso kuti IDN 6556 ndi PF 03491390, ndi yoyamba mu kalasi caspase inhibitor mu mayesero a zachipatala pofuna kuchiza matenda a chiwindi. Emricasan (IDN-6556) imachepetsa kuvulala kwa chiwindi ndi fibrosis mu chitsanzo cha murine cha steatohepatitis yopanda mowa. IDN6556 imathandizira kujambulidwa kwachisumbu chambiri mumtundu waporcine islet autotransplant. Oral IDN-6556 ikhoza kuchepetsa ntchito ya aminotransferase kwa odwala omwe ali ndi matenda a hepatitis C. PF-03491390 yogwiritsidwa ntchito pamlomo imasungidwa m'chiwindi kwa nthawi yaitali ndi mawonekedwe otsika kwambiri, omwe amachititsa hepatoprotective zotsatira motsutsana ndi kuwonongeka kwa chiwindi cha alpha-fas mu chitsanzo cha mbewa. . |
| Chithunzi cha CPD100615 | Q-VD-Oph | QVD-OPH, yomwe imadziwikanso kuti Quinoline-Val-Asp-Difluorophenoxymethylketone, ndi wide spectrum caspase inhibitor yokhala ndi antiapoptotic properties. Q-VD-OPh imalepheretsa kukwapula kwa mwana wakhanda mu makoswe a P7: gawo la jenda. Q-VD-OPh ili ndi zotsatira zotsutsana ndi khansa ya m'magazi ndipo imatha kuyanjana ndi ma analogi a vitamini D kuonjezera chizindikiro cha HPK1 m'maselo a AML. Q-VD-OPh imachepetsa apoptosis yopwetekedwa ndi kupwetekedwa mtima komanso imathandizira kubwezeretsanso ntchito ya mwendo wakumbuyo mu makoswe pambuyo pa kuvulala kwa msana. |
| Chithunzi cha CPD100614 | Z-DEVD-FMK | Z-DEVD-fmk ndi cell-permeable, yosasinthika inhibitor ya caspase-3. Caspase-3 ndi cysteineyl aspartate-specific protease yomwe imagwira ntchito yayikulu mu apoptosis. |
| CPD100613 | Z-IETD-FMK | MDK4982, yomwe imadziwikanso kuti Z-IETD-FMK, ndi yamphamvu, yopitikizidwa ndi cell, yosasinthika inhibitor ya caspase-8 ndi granzyme B., Caspase-8 Inhibitor II imayang'anira zochitika zamoyo za Caspase-8. MDK4982 imalepheretsa bwino apoptosis yoyambitsidwa ndi kachilombo ka fuluwenza m'maselo a HeLa. MDK4982 imalepheretsanso granzyme B. MDK4982 ili ndi CAS#210344-98-2. |
| CPD100612 | Z-VAD-FMK | Z-VAD-FMK ndi cell-permeable, yosasinthika pan-caspase inhibitor. Z-VAD-FMK imalepheretsa kukonza caspase ndi kulowetsedwa kwa apoptosis m'maselo otupa mu vitro (IC50 = 0.0015 - 5.8 mM). |
| CPD100611 | Belnacasan | Belnacasan, yomwe imadziwikanso kuti VX-765, idapangidwa kuti iziletsa Caspase, yomwe ndi puloteni yomwe imayendetsa kupanga ma cytokines awiri, IL-1b ndi IL-18. VX-765 yasonyezedwa kuti imaletsa kukomoka koopsa m'mafanizo a preclinical. Kuphatikiza apo, VX-765 yawonetsa zochitika mumitundu yoyambirira ya khunyu. VX-765 inali itayikidwa pa odwala oposa 100 mu mayesero a chipatala a gawo-I ndi gawo-IIa okhudzana ndi matenda ena, kuphatikizapo mayesero a chipatala a 28-day-IIa odwala psoriasis. Yatsiriza gawo la chithandizo cha gawo-IIa lachidziwitso chachipatala cha VX-765 chomwe chinalembetsa pafupifupi odwala 75 omwe ali ndi khunyu yosamva mankhwala. Mayesero achipatala akhungu, osasinthika, oyendetsedwa ndi placebo adapangidwa kuti ayese chitetezo, kulekerera ndi zochitika zachipatala za VX-765. |
