GDC-9545

GDC-9545
  • Name: GDC-9545
  • Catalog No.: CPD101731
  • CAS No.: 1953133-47-5
  • Molecular Weight: 522.55
  • Chemical Formula: C27 H31 F5 N4 O
  • For scientific research only, not for patients.

    Product Detail

    Product Tags

    Pack Size Availability Price (USD)
    10mg In Stock 420
    100mg In Stock 890
    1g In Stock 3300

    Chemical Name:

    Giredestrant, also known as GDC-9545 and RG6171, is a SERD. GDC-9545 is an orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD GDC-9545 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation.

    SMILES Code: 

    C[C@@H]1CC(C2=C(N3)C=CC=C2)=C3[C@@H](C4=C(C=C(C=C4F)NC5CN(C5)CCCF)F)N1CC(CO)(F)F

    InChi Code:

    InChI=1S/C27H31F5N4O/c1-16-9-20-19-5-2-3-6-23(19)34-25(20)26(36(16)14-27(31,32)15-37)24-21(29)10-17(11-22(24)30)33-18-12-35(13-18)8-4-7-28/h2-3,5-6,10-11,16,18,26,33-34,37H,4,7-9,12-15H2,1H3/t16-,26-/m1/s1

    InChi Key:

    GQCXHIKRWBIQMD-AKJBCIBTSA-N

    Keyword:

    1953133-47-5;CAS:1953133-47-5;CAS:1953133-47-5;GDC-9545; GDC9545; GDC 9545; RG6171; RG-6171; RG 6171; Giredestrant

    Solubility: Soluble in DMSO

    Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

    Description: 

    Giredestrant, also known as GDC-9545 and RG6171, is a SERD. GDC-9545 is an orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD GDC-9545 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation.

    Target: Selective ER antagonists




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