Nirogacestat

Nirogacestat
  • Name: Nirogacestat
  • Catalog No.: CPD107464
  • CAS No.: 1290543-63-3
  • Molecular Weight: 489.64
  • Chemical Formula: C27 H41 F2 N5 O
  • For scientific research only, not for patients.

    Product Detail

    Product Tags

    Pack Size Availability Price (USD)
    10mg In Stock 350
    100mg In Stock 680
    1g In Stock 2950

    Chemical Name:

    (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide

    SMILES Code: 

    CCC[C@H](N[C@@H]1CC2=C(C=C(F)C=C2F)CC1)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O

    InChi Code:

    InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1

    InChi Key:

    VFCRKLWBYMDAED-REWPJTCUSA-N

    Keyword:

    1290543-63-3;CAS:1290543-63-3;CAS:1290543-63-3;Nirogacestat;PF-3084014;PF3084014;PF 3084014

    Solubility: Soluble in DMSO, not in water

    Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

    Description: 

    Nirogacestat, also known as PF-03084014, is a potent and selective gamma secretase (GS) inhibitor with potential antitumor activity. PF-03084014 binds to GS, blocking proteolytic activation of Notch receptors. Nirogacestat enhances the Antitumor Effect of Docetaxel in Prostate Cancer. Nirogacestat enhances docetaxel-mediated tumor response and provides a rationale to explore GSIs as adjunct therapy in conjunction with docetaxel for men with CRPC (castration-resistant prostate cancer).

    Target: Reversible, non competitive, selective γ- Secretase inhibitor




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