| CAT # | Izina ryibicuruzwa | Ibisobanuro |
| CPD100616 | Emricasan | Emricasan, uzwi kandi ku izina rya IDN 6556 na PF 03491390, ni inzitizi ya mbere mu cyiciro cya caspase inhibitor mu bigeragezo bivura indwara z’umwijima. Emricasan (IDN-6556) igabanya imvune yumwijima na fibrosis muburyo bwa murine bwa steatohepatitis idafite inzoga. IDN6556 yorohereza marginal mass islet engmentment ya porcine islet autotransplant moderi. IDN-6556 yo mu kanwa irashobora kugabanya ibikorwa bya aminotransferase kubarwayi barwaye hepatite idakira C. PF-03491390 itangwa mu kanwa igumana umwijima igihe kirekire hamwe na sisitemu nkeya, ikagira ingaruka za hepatoprotective kurwanya alfa-fas iterwa n'umwijima muburyo bw'imbeba. . |
| CPD100615 | Q-VD-Oph | QVD-OPH, izwi kandi nka Quinoline-Val-Asp-Difluorophenoxymethylketone, ni inzitizi nini ya caspase inhibitor ifite imiti igabanya ubukana. Q-VD-OPh irinda indwara ya neonatal mu mbeba ya P7: uruhare rwuburinganire. Q-VD-OPh ifite ingaruka zo kurwanya leukemia kandi irashobora gukorana na vitamine D igereranya kugirango HPK1 yerekana ibimenyetso muri selile AML. Q-VD-OPh igabanya apoptose iterwa nihungabana kandi igahindura imikorere yimikorere yinyuma yimbeba nyuma yimvune yumugongo |
| CPD100614 | Z-DEVD-FMK | Z-DEVD-fmk ni selile-yinjira, idasubirwaho inhibitor ya caspase-3. Caspase-3 ni poroteyine yihariye ya sisitemuine igira uruhare runini muri apoptose. |
| CPD100613 | Z-IETD-FMK | MDK4982, izwi kandi nka Z-IETD-FMK, ni imbaraga zikomeye, zinjira mu ngirabuzimafatizo, zidashobora gusubira inyuma za caspase-8 na granzyme B., Caspase-8 Inhibitor II igenzura ibikorwa by’ibinyabuzima bya Caspase-8. MDK4982 ibuza neza virusi ya grippe iterwa na selile ya HeLa. MDK4982 nayo ibuza granzyme B. MDK4982 ifite CAS # 210344-98-2. |
| CPD100612 | Z-VAD-FMK | Z-VAD-FMK ni selile-yinjira, idasubirwaho pan-caspase inhibitor. Z-VAD-FMK ibuza gutunganya caspase no kwinjiza apoptose muri selile yibibyimba muri vitro (IC50 = 0.0015 - 5.8 mM). |
| CPD100611 | Belnacasan | Belnacasan, izwi kandi ku izina rya VX-765, yagenewe kubuza Caspase, iyo ikaba ari enzyme igenzura ibisekuruza bibiri bya cytokine, IL-1b na IL-18. VX-765 yerekanwe kubuza gufatwa gukabije muburyo bwa preclinical. Mubyongeyeho, VX-765 yerekanye ibikorwa muburyo bwa preclinical epilepsy idakira. VX-765 yari imaze kwipimisha ku barwayi barenga 100 mu cyiciro cya mbere cy’icyiciro cya I n’icyiciro cya IIa kijyanye n’izindi ndwara, harimo n’iminsi 28 y’amavuriro ya IIa ku barwayi barwaye psoriasis. Yasoje icyiciro cyo kuvura icyiciro cya IIa cyamavuriro ya VX-765 yandikishije abarwayi bagera kuri 75 bafite igicuri kitarwanya imiti. Ikigeragezo cya kabiri-gihumye, cyateganijwe, kigenzurwa na platbo cyateguwe hagamijwe gusuzuma umutekano, kwihanganira ibikorwa byubuvuzi bya VX-765. |
