| CAT # | Ingoa Hua | Whakaahuatanga |
| CPD100587 | Phlorizin | Ko te Phlorizin, e kiia ana ko te phloridzin, he glucoside o te phloretin, he dihydrochalcone, he whanau o nga flavonoids paihikara, he roopu iti kei roto i te huarahi whakahiato phenylpropanoid rereke i roto i nga tipu. Ko te Phlorizin he aukati whakataetae o SGLT1 me SGLT2 no te mea ka whakataetae ia ki te D-glucose mo te here ki te kawe; ka whakaitihia te kawe huka renal, ka whakaheke i te nui o te huka i roto i te toto. I rangahauhia a Phlorizin hei rongoa rongoa mo te mate huka momo 2, engari mai i tera wa kua whakakapihia e te maha atu o nga tohu taapiri me te whai hua, penei i te canagliflozin me te dapagliflozin. |
| CPD0045 | Ipragliflozin | Ko te Ipragliflozin, e mohiotia ana ko ASP1941, he aukati SGLT2 kaha me te whiriwhiri mo te maimoatanga o te mate huka momo 2. Ko te maimoatanga o te Ipragliflozin i pai ake te whakahaere glycemic i te wa e taapirihia ana ki te rongoa metformin ka pa atu pea ki te whakaheke taumaha me te heke o te pehanga toto ka whakaritea ki te placebo. Ko te Ipragliflozin te whakapai ake ehara i te hyperglycemia anake, engari ano hoki te mate huka/te mate nui e pa ana ki te mate o nga kiore mate huka momo 2. I whakaaetia mo te whakamahi i Japan i te tau 2014 |
| CPD100585 | Tofogliflozin | Ko te Tofogliflozin, e mohiotia ana ko CSG 452, he kaha me te kaha ki te whiriwhiri i te aukati SGLT2 i raro i te whakawhanaketanga mo te maimoatanga o te mate huka mellitus. Ko te Tofogliflozin te whakapai ake i te mana glycemic me te whakaheke i te taumaha o te tinana ki nga turoro me te mate huka momo 2. Ko te Tofogliflozin i runga i te horopeta ka aukati i te urunga o te huka ki roto i nga pūtau tubular. Ko te whakakitenga nui o te huka (30?mM) mo te 4 me te 24?h i tino piki ake te whakaputanga ahotea oxidative i roto i nga pūtau tubular, i pehia e te maimoatanga o te tofogliflozin, he antioxidant N-acetylcysteine (NAC). |
| CPD100583 | Empagliflozin | Ko te Empagliflozin, e mohiotia ana ko BI10773 (ingoa hokohoko Jardiance), he rongoa kua whakaaetia mo te maimoatanga o te mate huka momo 2 i roto i nga pakeke i te tau 2014. I whakawhanakehia e Boehringer Ingelheim me Eli Lilly me Kamupene. Ko te Empagliflozin he aukati o te konutai konutai co-transporter-2 (SGLT-2), me te mea ka uru te huka i roto i te toto ki nga whatukuhu, ka whakakorea ki te mimi. Ko te Empagliflozin he aukati o te konutai glucose co-transporter-2 (SGLT-2), ka kitea tata anake i roto i nga tubules tata o nga waahanga nephronic i roto i nga whatukuhu. Ko te SGLT-2 e 90 paihēneti o te whakaurunga o te huka ki roto i te toto. |
| CPD100582 | Canagliflozin | Ko Canagliflozin (INN, ingoa hokohoko Invokana) he rongoa mo te maimoatanga o te mate huka momo 2. I whakawhanakehia e Mitsubishi Tanabe Pharma, ka hokona i raro i te raihana a Janssen, he wehenga o Johnson & Johnson. Ko te Canagliflozin he aukati o te momo 2 konutai-glucose transport protein (SGLT2), ko te kawenga mo te 90% o te reabsorption glucose i roto i te whatukuhu. Ma te aukati i tenei kaikawe ka whakakorehia te huka toto ma te mimi. I te Poutu-te-rangi 2013, ko te canagliflozin te aukati SGLT2 tuatahi kua whakaaetia i te United States. |
| CPD0003 | Dapagliflozin | Ko te Dapagliflozin, e mohiotia ana ko BMS-512148, he rongoa hei rongoa mo te mate huka momo 2 i whakaaetia i te tau 2012 e te FDA. Ko te Dapagliflozin te aukati i te momo 2 o nga pūmua kawe konutai-glucose (SGLT2) e kawe ana mo te 90% o te reabsorption glucose i roto i te whatukuhu. Ma te aukati i tenei taputapu kawe ka whakahekehia te huka toto ma te mimi. I roto i nga whakamatautau haumanu, ka whakahekehia e te dapagliflozin te HbA1c ma te 0.6 ki nga tohu paheketanga placebo ina taapiri atu ki te metformin. |
