• Name: Tropifexor
  • Catalog No.: CPD1549
  • CAS No.: 1383816-29-2
  • Molecular Weight: 603.58
  • Chemical Formula: C29H25F4N3O5S
  • For scientific research only, not for patients.

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    Pack Size Availability Price (USD)
    100mg In stock 800
    1g In stock 1850
    5g In stock 7400
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    Chemical Name:

    2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid

    SMILES Code: 


    InChi Code:


    InChi Key:



    Tropifexor, LJN-452, LJN452, LJN 452, 1383816-29-2

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).


    Tropifexor (compound 1) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM. Robust induction of both BSEP and SHP genes is observed in primary cells by Tropifexor in a concentration-dependent manner. BSEP induction above vehicle (DMSO) control is observed at concentrations as low as 1 nM, while strong induction of SHP (15-fold above vehicle) is observed at 10 nM and modest induction of SHP at 1 nM (3-fold)[1].

    Target: FXR

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