||GDC-0077 is an orally available PI3K inhibitor with potential antineoplastic activity.
||IPI549 is a potent and selective PI3Kγ Inhibitor with an IC50 of 16 nM.
||GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). GDC-0326 achieves a very high level of selectivity over other kinases. GDC-0326 has low plasma CL in human.
||AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity.
||PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor.
||GDC-0077 is an orally available and selective PI3K inhibitor (IC50 = 0.038 + 0.003 nM) with > 300-fold selective over other Class I PI3K isoforms.