CAT # Product Name Description
CPD3508 GSK547 GSK547 is a highly selective and potent inhibitor of RIP1 kinase that targets RIP1 in vivo
CPDD0980 CPDD0980
CPD2801 OSI-027 OSI-027 is an orally bioavailable mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity. mTOR kinase inhibitor OSI-027 binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR is a serine/threonine kinase that is upregulated in some tumors and plays an important role downstream in the PI3K/Akt/mTOR signaling pathway. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
CPD3504 BAY-218
CPD2807 BAY-293 BAY-293 is a potent SOS1 inhibitor that blocks RAS activation via disruption of the RAS-SOS1 interaction. BAY-293) selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21 nM and is a valuable chemical probe for future investigations.
CPD3213 CPD3213
CPD3212 CPD3212
CPD3211 CPD3211
CPD3210 CPD3210
CPD3209 CPD3209
CPD3208 CPD3208
CPD3207 CPD3207
CPD3206 CPD3206
CPD3205 CPD3205
CPD3204 CPD3204
CPD3203 CPD3203
CPD3202 CPD3202
CPD3201 CPD3201
CPD3200 CPD3200
CPD2809 CPD2809 AMG-510 is a potent KRAS G12C covalent inhibitor. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells
CPD3502 CPD3502
CPD2810 CPD2810
CPD2810-B4 CPD2810-B4
CPD2810-B3 CPD2810-B3

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