RO7656594; GDC-2992

Chemical Name:

N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-4-(4-((4-(2-((S)-2,6-dioxopiperidin-3-yl)-1-oxo-1,2-dihydrophthalazin-6-yl)piperazin-1-yl)methyl)piperidin-1-yl)benzamide

SMILES Code: 

ClC1=CC(O[C@H]2C(C)(C)[C@H](NC(C3=CC=C(N4CCC(CN5CCN(C6=CC=C7C(C=NN([C@@H]8C(NC(CC8)=O)=O)C7=O)=C6)CC5)CC4)C=C3)=O)C2(C)C)=CC=C1C#N

InChi Code:

InChI=1S/C45H51ClN8O5/c1-44(2)42(45(3,4)43(44)59-34-11-7-30(25-47)36(46)24-34)50-39(56)29-5-8-32(9-6-29)52-17-15-28(16-18-52)27-51-19-21-53(22-20-51)33-10-12-35-31(23-33)26-48-54(41(35)58)37-13-14-38(55)49-40(37)57/h5-12,23-24,26,28,37,42-43H,13-22,27H2,1-4H3,(H,50,56)(H,49,55,57)/t37-,42-,43-/m0/s1

InChi Key:

PAELKDHSDBUTGE-SCBUQILPSA-N

Keyword:

2753651-10-2；CAS：2753651-10-2；CAS:2753651-10-2；GDC-2992; GDC2992; GDC 2992; RO7656594; RO 7656594; RO-7656594

Solubility: 

Storage: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Description: 

GDC-2992 (Compound 28A) is an orally active androgen receptor (AR) degrader.

Target: AR