• Name: BLU-285
  • Catalog No.: CPD1212
  • CAS No.: 1703793-34-3
  • Molecular Weight: 498.56
  • Chemical Formula: C26H27FN10
  • For scientific research only, not for patients.

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    1g In stock 900
    5g In stock 3600
    10g In stock 6200
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    BLU-285, BLU 285, BLU285, Avapritinib

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).


    Avapritinib (BLU-285) has demonstrated biochemical in vitro activity on the KIT exon 17 mutant enzyme, KIT D816V (IC50=0.27 nM). Cellular activity of Avapritinib on KIT D816 mutants is measured by autophosphorylation in the human mast cell leukemia cell line HMC1.2, and the P815 mouse mastocytoma cell line with IC50=4 and 22 nM, respectively. In Kasumi-1 cells, a t(8;21)-positive AML cell line with a KIT exon 17 N822K mutation, Avapritinib potently inhibits KIT N822K mutant autophosphorylation (IC50=40 nM), downstream signaling, as well as cellular proliferation (IC50=75 nM)[1].

    Target: KIT

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