RMC-5127

Chemical Name:

SMILES Code: 

C[C@H](OC)C(N=C1)=[C@@]([C@@]2=C(CC(C)(C)COC([C@H]3NN(C([C@@H](NC([C@H]4OC[C@@H]4C)=O)[C@H](N5CC6(COC6)C5)C7=NC8=CS7)=O)C9CC3C9)=O)C%10=C(C=CC8=C%10)N2CCOC%11CCOCC%11)C=C1N%12CCN(C%13CC%13)CC%12

InChi Code:

InChI=1S/C57H75N9O9S/c1-33-26-74-51(33)52(67)60-48-50(64-28-57(29-64)31-72-32-57)53-59-44(27-76-53)35-6-9-45-41(22-35)43(24-56(3,4)30-75-55(69)47-36-20-38(21-36)66(61-47)54(48)68)49(65(45)16-19-73-40-10-17-71-18-11-40)42-23-39(25-58-46(42)34(2)70-5)63-14-12-62(13-15-63)37-7-8-37/h6,9,22-23,25,27,33-34,36-38,40,47-48,50-51,61H,7-8,10-21,24,26,28-32H2,1-5H3,(H,60,67)/t33-,34?,36?,38?,47-,48-,50-,51-/m0/s1

InChi Key:

JFORVBRBJPBOTP-OQZXZADOSA-N

Keyword:

RMC-5127; RMC5127; RMC 5127

Solubility: 

Storage: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Description: 

RMC-5127 is a mutation selective triple complex RASG12V inhibitor with oral activity and brain permeability.

Target: RASG12V