• Name: BMS-986195
  • Catalog No.: CPDD1640
  • CAS No.: 1912445-55-6
  • Molecular Weight: 370.4284
  • Chemical Formula: C20H23FN4O2 
  • For scientific research only, not for patients.

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    BMS-986195, BMS 986195, BMS986195, 1912445-55-6

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).


    BMS-986195 is a potent, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK), a member of the Tec family of non-receptor tyrosine kinases essential in antigen-dependent B-cell signaling and function. BMS-986195 is more than 5000-fold selective for BTK over all kinases outside of the Tec family, and selectivity ranges from 9- to 1010-fold within the Tec family. BMS-986195 inactivated BTK in human whole blood with a rapid rate of inactivation (3.5×10-4 nM-1·min-1) and potently inhibited antigen-dependent interleukin-6 production, CD86 expression and proliferation in B cells (IC50 <1 nM) without effect on antigen-independent measures in the same cells.

    Target: BTK

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