Nazartinib; EGF816; NVS-816

Nazartinib; EGF816; NVS-816
  • Name: Nazartinib; EGF816; NVS-816
  • Catalog No.: CPDB3615
  • CAS No.: "1508250-71-2 "
  • Molecular Weight: 495.02
  • Chemical Formula: C26H31ClN6O2
  • For scientific research only, not for patients.

    Product Detail

    Product Tags

    Pack Size Availability Price (USD)
    25mg In Stock 290
    50mg In Stock 450
    100mg In Stock 630
    1g In Stock 1600
    More Sizes Get Quotes Get Quotes

    Chemical Name:


    SMILES Code: 


    InChi Code:


    InChi Key:



    Nazartinib ,EGF816, EGF-816, EGF 816, NVS-816, 1508250-71-2

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months)


    Nazartinib, also known as EGF816 and NVS-816, is an orally available, irreversible, third-generation, mutant-selective epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. EGF816 covalently binds to and inhibits the activity of mutant forms of EGFR, including the T790M EGFR mutant, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGF816 preferentially inhibits mutated forms of EGFR including T790M, a secondarily acquired resistance mutation, and may have therapeutic benefits in tumors with T790M-mediated resistance when compared to other EGFR tyrosine kinase inhibitors.

    Target: EGFR

  • Previous:
  • Next:

  • Related Products

    WhatsApp Online Chat !