• Name: BLU9931
  • Catalog No.: CPD3610
  • CAS No.: 1538604-68-0
  • Molecular Weight: 509.38
  • Chemical Formula: C26H22Cl2N4O3
  • For scientific research only, not for patients.

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    Pack Size Availability Price (USD)
    100mg In stock 220
    300mg In stock 500
    1g In stock 1350
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    BLU-9931, BLU9931, BLU 9931, 1538604-68-0

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).


    In MDA-MB-453 cells, BLU9931 potently inhibits phosphorylation of FGFR4 signaling pathway. BLU9931 inhibits proliferation of HCC cell lines that express an intact FGFR4 signaling complex, such as Hep 3B, HUH-7, and JHH-7 cell lines, with EC50 of <1 μM. BLU9931 also inhibits proliferation in PDX-derived cell lines with an intact FGFR4 signaling pathway[1]. BLU9931 induces tumor shrinkage in hepatocellular carcinoma models that express a functioning ligand/receptor complex consisting of FGF19/FGFR4/KLB and adds to a growing list of anti-FGFR4 agents[2].

    Target: FGFR4

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