• Name: BI-847325
  • Catalog No.: CPDB0157
  • CAS No.: 1207293-36-4
  • Molecular Weight: 464.6
  • Chemical Formula: C29H28N4O2
  • For scientific research only, not for patients.

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    Pack Size Availability Price (USD)
    100mg In Stock 400
    500mg In Stock 950
    1g In Stock 1400
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    InChi Code:


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    BI-847325, BI847325, BI 847325, 1207293-36-4

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months)


    BI-847325 is a selective dual MEK/Aurora kinase inhibitor with IC50 values of 3, 25, 15, 25, and 4 nM for X. laevis Aurora B, human Aurora A and Aurora C, and human MEK1 and MEK2, respectively. It can inhibit the growth and survival of both treatment-naive and drug-resistant melanoma cell lines, decreasing the expression of MEK and Mcl-1 while increasing the expression of pro-apoptotic protein Bim. At 70 mg/kg, BI-847325 induces apoptosis in treatment-naive and drug-resistant xenografted melanoma in vivo.

    Target: MEK/Aurora

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