Adagrasib; MRTX849

Chemical Name:

2-((S)-4-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile

SMILES Code: 

O=C(C(F)=C)N([C@@H](CC#N)C1)CCN1C2=NC(OC[C@H]3N(C)CCC3)=NC4=C2CCN(C5=CC=CC6=C5C(Cl)=CC=C6)C4

InChi Code:

InChI=1S/C32H35ClFN7O2/c1-21(34)31(42)41-17-16-40(18-23(41)11-13-35)30-25-12-15-39(28-10-4-7-22-6-3-9-26(33)29(22)28)19-27(25)36-32(37-30)43-20-24-8-5-14-38(24)2/h3-4,6-7,9-10,23-24H,1,5,8,11-12,14-20H2,2H3/t23-,24-/m0/s1

InChi Key:

PEMUGDMSUDYLHU-ZEQRLZLVSA-N

Keyword:

2326521-71-3；CAS：2326521-71-3；CAS:2326521-71-3；MRTX849；MRTX-849；MRTX 849；Adagrasib

Solubility: Soluble in DMSO

Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Description: 

Adagrasib (MRTX849) is a potent, orally available, mutation-selective covalent inhibitor of KRAS G12C.

Target: KRAS G12C