Evofosfamide; TH 302
Product Detail
Product Tags
| Pack Size | Availability | Price (USD) |
| 100mg | In Stock | 360 |
| 1g | In Stock | 1000 |
| More Sizes | Get Quotes | Get Quotes |
Chemical Name:
N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester
SMILES Code:
O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C
InChi Code:
InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/h6H,2-5,7H2,1H3,(H2,13,14,19)
InChi Key:
UGJWRPJDTDGERK-UHFFFAOYSA-N
Keyword:
918633-87-1；CAS：918633-87-1；CAS:918633-87-1；TH302; TH 302; TH-302. Evofosfamide
Solubility: Soluble in DMSO
Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months)
Description:
Evofosfamide, also known as TH-302, is a hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI).
Target: DNA Alkylating Agent
