Infigratinib; NVPBGJ-398; BGJ398

Infigratinib; NVPBGJ-398; BGJ398
  • Name: Infigratinib; NVPBGJ-398; BGJ398
  • Catalog No.: CPD100211
  • CAS No.: 872511-34-7
  • Molecular Weight: 560.47
  • Chemical Formula: C26 H31 Cl2 N7 O3
  • For scientific research only, not for patients.

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    Chemical Name:

    3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea

    SMILES Code: 

    ClC1=C(C(Cl)=C(C=C1OC)OC)NC(N(C2=CC(NC3=CC=C(C=C3)N4CCN(CC4)CC)=NC=N2)C)=O

    InChi Code:

    ClC1=C(C(Cl)=C(C=C1OC)OC)NC(N(C2=CC(NC3=CC=C(C=C3)N4CCN(CC4)CC)=NC=N2)C)=O

    InChi Key:

    QADPYRIHXKWUSV-UHFFFAOYSA-N

    Keyword:

    872511-34-7;CAS:872511-34-7;CAS:872511-34-7;NVPBGJ398; NVPBGJ 398; NVPBGJ-398; BGJ398; BGJ-398; BG J398; Infigratinib

    Solubility: Soluble in DMSO, not in water

    Storage: -20°C

    Description: 

    Infiglatinib (BGJ-398; NVP-BGJ398) is an effective inhibitor of the FGFR family, with IC50 values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for inhibiting FGFR1, FGFR2, FGFR3, and FGFR4, respectively.

    Target: FGFR




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