Infigratinib; NVPBGJ-398; BGJ398

For scientific research only, not for patients.
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Chemical Name:
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea
SMILES Code:
ClC1=C(C(Cl)=C(C=C1OC)OC)NC(N(C2=CC(NC3=CC=C(C=C3)N4CCN(CC4)CC)=NC=N2)C)=O
InChi Code:
ClC1=C(C(Cl)=C(C=C1OC)OC)NC(N(C2=CC(NC3=CC=C(C=C3)N4CCN(CC4)CC)=NC=N2)C)=O
InChi Key:
QADPYRIHXKWUSV-UHFFFAOYSA-N
Keyword:
872511-34-7;CAS:872511-34-7;CAS:872511-34-7;NVPBGJ398; NVPBGJ 398; NVPBGJ-398; BGJ398; BGJ-398; BG J398; Infigratinib
Solubility: Soluble in DMSO, not in water
Storage: -20°C
Description:
Infiglatinib (BGJ-398; NVP-BGJ398) is an effective inhibitor of the FGFR family, with IC50 values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for inhibiting FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
Target: FGFR

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