• Name: IT-901
  • Catalog No.: CPDB1661
  • CAS No.: 1584121-99-2
  • Molecular Weight: 342.369
  • Chemical Formula: C17H14N2O4S
  • For scientific research only, not for patients.

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    100mg In Stock 500
    500mg In Stock 800
    1g In Stock 1200
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    IT-901, IT901, IT 901, 1584121-99-2

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).


    "IT-901 is a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB-Controlled Oxidative Stress Responses. IT-901 potently inhibits the NF-κB subunit c-Rel. IT-901 suppressed graft-versus-host disease while preserving graft-versus-lymphoma activity during allogeneic transplantation. Further preclinical assessment of IT-901 for the treatment of human B-cell lymphoma revealed antitumor properties in vitro and in vivo without restriction to NF-κB-dependent lymphoma. IT-901 did not elicit increased levels of reactive oxygen species in normal leukocytes, illustrating its cancer selective properties. IT-901 is a novel therapeutic agent to treat human lymphoid tumors and ameliorate graft-versus-host disease. "

    Target: NF-kB

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