Bardoxolone methyl

Bardoxolone methyl
  • Name: RTA-402; NSC-713200; TP-155C; Methyl-CDDO; Methyl CDDO; Bardoxolone methyl
  • Catalog No.: CPDD0995
  • CAS No.: 218600-53-4
  • Molecular Weight: 505.69
  • Chemical Formula: C32H43NO4
  • For scientific research only, not for patients.

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    Chemical Name:

    (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

    SMILES Code: 


    InChi Code:


    InChi Key:



    Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months)


    The synthetic oleanane triterpenoid CDDO (Item No. 81035) is a Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. The C-28 methyl ester of CDDO (CDDO methyl ester) blocks the cellular synthesis of inducible nitric oxide synthase (iNOS) and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.11 nM. It induces apoptosis, induces differentiation, and inhibits the inflammatory response in various tumor cells through inhibition of IκBα kinase/NF-κB signaling. CDDO methyl ester has potent antidiabetic activity, reducing proinflammatory cytokine expression in high fat diet-fed type 2 diabetic mice and in Leprdb/db mice and triggering AMP-activated protein kinase and LKB1 activation in muscle and liver

    Target: NF-kB

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