BI-2852

BI-2852
  • Name: BI-2852
  • Catalog No.: CPD101246
  • CAS No.: 2375482-51-0
  • Molecular Weight: 516.59
  • Chemical Formula: C31 H28 N6 O2
  • For scientific research only, not for patients.

    Product Detail

    Product Tags

    Pack Size Availability Price (USD)

    Chemical Name:

    (S)-5-hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl)-1H-indol-3-yl)isoindolin-1-one

    SMILES Code: 

    OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62)N7)=C1C7=O

    InChi Code:

    InChI=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15-27-29(24-4-2-3-5-26(24)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2-13,16,18,30,32,34,38H,14-15,17H2,1H3,(H,35,39)/t30-/m0/s1

    InChi Key:

    JYEQLXOWWLNVDX-PMERELPUSA-N

    Keyword:

    Solubility: 

    Storage: 

    Description: 

    BI-2852 is a potent KRAS inhibitor that binds with nanomolar affinity to a pocket, thus far perceived to be "undruggable," between switch I and II on RAS. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitors because it binds to a different pocket present in both the active and inactive forms of KRAS. BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

    Target: KRAS


  • Previous:
  • Next:

  • Related Products

    
    WhatsApp Online Chat !