Adavivint
Product Detail
Product Tags
| Pack Size | Availability | Price (USD) |
| 100mg | In Stock | 500 |
| 500mg | In Stock | 800 |
| 1g | In Stock | 1200 |
| More Sizes | Get Quotes | Get Quotes |
Chemical Name:
N-(5-{3-[7-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl}pyridin-3-yl)-3-methylbutanamide
SMILES Code:
CC(C)CC(NC1=CC(C2=CC3=C(NN=C3C(N4)=NC5=C4C(C6=CC=CC(F)=C6)=CN=C5)C=C2)=CN=C1)=O
InChi Code:
InChI=1S/C29H24FN7O/c1-16(2)8-26(38)33-21-10-19(12-31-13-21)17-6-7-24-22(11-17)28(37-36-24)29-34-25-15-32-14-23(27(25)35-29)18-4-3-5-20(30)9-18/h3-7,9-16H,8H2,1-2H3,(H,33,38)(H,34,35)(H,36,37)
InChi Key:
AQDWDWAYVBQMAM-UHFFFAOYSA-N
Keyword:
Adavivint, SM04690, SM-04690, SM 04690, 1467093-03-3
Solubility: Soluble in DMSO
Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).
Description:
A novel small molecule Wnt pathway inhibitor with EC50 of 3 nM in vitro; induces hMSC differentiation into mature, functional chondrocytes and decreases cartilage catabolic marker levels; significantly improves Osteoarthritis Research Society International (OARSI) histology scores and biomarkers in a rodent OA model.
Target: WNT
