• Name: PRN1008
  • Catalog No.: CPDD1644
  • CAS No.: 1575596-29-0
  • Molecular Weight: 665.323
  • Chemical Formula: C36H40FN9O3 
  • For scientific research only, not for patients.

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    PRN1008, PRN-1008, PRN 1008,1575596-29-0

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).


    PRN1008 is a potent, selective and reversible covalent inhibitor of BTK ((IC50 = 1.3 ± 0.5 nM).) with extended PD effects in vivo. PRN1008 was safe and well tolerated after single and 10 day dosing in humans. Dosing to achieve > 90% occupancy after a dose results in consistent and prolonged target occupancy. BTK target coverage with a daily dose of ≥300mg reached therapeutic levels based on translational studies in a rat model of arthritis. These data support continued development of PRN1008 as a therapeutic agent for rheumatoid arthritis.

    Target: BTK

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