Mevrometostatum; mevrometostat; PF-06821497

Chemical Name:

(R)-5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one

SMILES Code: 

[H][C@@](C1=C(Cl)C2=C(CCN(CC3=C(OC)C=C(C)NC3=O)C2=O)C(Cl)=C1)(OC)C4COC4

InChi Code:

InChI=1S/C22H24Cl2N2O5/c1-11-6-17(29-2)15(21(27)25-11)8-26-5-4-13-16(23)7-14(19(24)18(13)22(26)28)20(30-3)12-9-31-10-12/h6-7,12,20H,4-5,8-10H2,1-3H3,(H,25,27)

InChi Key:

RXCVUHMIWHRLDF-UHFFFAOYSA-N

Keyword:

1844849-10-0；CAS：1844849-10-0；CAS:1844849-10-0；Mevrometostatum；mevrometostat；PF06821497；PF 06821497；PF-06821497

Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml DMSO: Slightly Soluble: 0.1-1 mg/ml Water: Slightly Soluble: 0.1-1 mg/ml

Storage: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Description: 

Mevrometostatum is an enhancer of zeste homolog 2 (EZH2) inhibitor.

Target: EZH2