CPD2809

CPD2809
  • Name: AMG-510
  • Catalog No.: CPD2809
  • CAS No.: 2252403-56-6 2296729-00-3 (racemate)
  • Molecular Weight: 560.23
  • Chemical Formula: C30H30F2N6O3
  • For scientific research only, not for patients.

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    Chemical Name:

    4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one

    SMILES Code: 

    O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1

    InChi Code:

    InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1

    InChi Key:

    NXQKSXLFSAEQCZ-SFHVURJKSA-N

    Keyword:

    AMG-510; AMG 510; AMG510

    Solubility: 

    Storage: 

    Description: 

    AMG-510 is a potent KRAS G12C covalent inhibitor. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells

    Target: KRAS


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