• Name: Vactosertib
  • Catalog No.: CPD3325
  • CAS No.: 1352608-82-2
  • Molecular Weight: 399.42
  • Chemical Formula: C22H18FN7
  • For scientific research only, not for patients.

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    500mg In Stock 800
    1g In Stock 1300
    5g In Stock 3800
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    Vactosertib, EW-7197, EW7197, EW 7197, 1352608-82-2

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months)


    Vactosertib, also known as EW-7197 is a potent ALK5 inhibitor. EW-7197 showed potent in vivo anti-metastatic activity, indicating its potential for use as an anti-cancer therapy. EW-7197 inhibits TGF-β/Smad signaling. EW-7197 abrogates TGF-β1-induced tumor cell migration and invasion. EW-7197 inhibits breast cancer metastasis to the lung.EW-7197 prolongs the life span of BALB/c 4T1 mice via inhibition of EMT. EW-7197 inhibits metastasis and enhances the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotopic grafted mice.

    Target: ALK

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