PRT-060318; PRT318; P142–76

PRT-060318; PRT318; P142–76
  • Name: PRT-060318; PRT318; P142–76
  • Catalog No.: CPDD3529
  • CAS No.: 1194961-19-7
  • Molecular Weight: 340.4
  • Chemical Formula: C18H24N6O
  • For scientific research only, not for patients.

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    Pack Size Availability Price (USD)
    500mg In Stock 900
    1g In Stock 1350
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    SMILES Code: 


    InChi Code:


    InChi Key:



    PRT-060318,PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months)


    PRT060318 is a potent and selective inhibitor of spleen tyrosine kinase (Syk; IC50 = 4 nM).It is selective, inhibiting 92% of Syk activity, while other kinases retain >70% activity, at a concentration of 50 nM in a panel of 270 kinases. PRT060318 inhibits convulxin-induced aggregation of human platelet-rich plasma (IC50 = 2.5 μM) in vitro and prevents thrombosis in a transgenic mouse model of heparin-induced thrombocytopenia. It induces chronic lymphocytic leukemia (CLL) B cell apoptosis and inhibits the secretion of chemokines CCL3, CCL4, and CXCL13.3 PRT060318 also inhibits CLL B cell chemotaxis and pseudoemperipolesis.

    Target: Syk

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