BAY 61-3606 2HCl

BAY 61-3606 2HCl
  • Name: BAY 61-3606 2HCl
  • Catalog No.: CPDD1851
  • CAS No.: 648903-57-5
  • Molecular Weight: 390.4
  • Chemical Formula: C20H18N6O3
  • For scientific research only, not for patients.

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    Chemical Name:

    2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide dihydrochloride

    SMILES Code: 


    InChi Code:


    InChi Key:



    BAY 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months)


    BAY 61-3606 is a potent (Ki = 7.5 nM) and selective inhibitor of Syk kinase. BAY 61-3606 inhibited not only degranulation (IC50 values between 5 and 46 nM) but also lipid mediator and cytokine synthesis in mast cells. BAY 61-3606 was highly efficacious in basophils obtained from healthy human subjects (IC50 = 10 nM) and seems to be at least as potent in basophils obtained from atopic (high serum IgE) subjects (IC50 = 8.1 nM). B cell receptor activation and receptors for Fc portion of IgG signaling in eosinophils and monocytes were also potently suppressed by BAY 61-3606.

    Target: Syk

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