OSI-027

OSI-027
  • Name: OSI-027
  • Catalog No.: CPD2801
  • CAS No.: 936890-98-1
  • Molecular Weight: 406.17
  • Chemical Formula: C21H22N6O3
  • For scientific research only, not for patients.

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    Chemical Name:

    trans-4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexanecarboxylic acid

    SMILES Code: 

    O=C([C@H]1CC[C@H](C2=NC(C(N3)=CC4=C3C(OC)=CC=C4)=C5C(N)=NC=NN52)CC1)O

    InChi Code:

    InChI=1S/C21H22N6O3/c1-30-15-4-2-3-13-9-14(25-16(13)15)17-18-19(22)23-10-24-27(18)20(26-17)11-5-7-12(8-6-11)21(28)29/h2-4,9-12,25H,5-8H2,1H3,(H,28,29)(H2,22,23,24)/t11-,12-

    InChi Key:

    JROFGZPOBKIAEW-HAQNSBGRSA-N

    Keyword:

    OSI027,OSI-027,OSI 027

    Solubility: 

    Storage: 

    Description: 

    OSI-027 is an orally bioavailable mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity. mTOR kinase inhibitor OSI-027 binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR is a serine/threonine kinase that is upregulated in some tumors and plays an important role downstream in the PI3K/Akt/mTOR signaling pathway. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

    Target: mTOR


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