ND-646

ND-646
  • Name: ND-646
  • Catalog No.: CPD5077
  • CAS No.: 1434639-57-2
  • Molecular Weight: 568.64
  • Chemical Formula: C28H32N4O7S
  • For scientific research only, not for patients.

    Product Detail

    Product Tags

    Pack Size Availability Price (USD)
    10mg In stock 300
    50mg In stock 500
    100mg In stock 800
    More Sizes Get Quotes Get Quotes

    Chemical Name:

    (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanamide

    SMILES Code: 

    O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC=CO5)S3)=O)C4=O

    InChi Code:

    InChI=1S/C28H32N4O7S/c1-16-21-24(33)32(28(2,3)26(29)34)27(35)31(25(21)40-22(16)23-30-11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10,12-13,15H2,1-4H3,(H2,29,34)/t20-/m0/s1

    InChi Key:

    HSRWXLIYNCKHRZ-FQEVSTJZSA-N

    Keyword:

    ND-646, ND646, ND 646, 1434639-57-2

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).

    Description: 

    ND-646 inhibits both ACC1 and ACC2 and therefore precludes the ability of ACC2 to compensate for ACC1 inhibition. ND-646 inhibits dimerization of recombinant human ACC2 BC domain (hACC2-BC) under native conditions; hACC2-BC migrates as a dimer in its absence and a monomer in its presence. In cell free systems, ND-646 inhibits enzymatic activity of recombinant human ACC1 (hACC1) with an IC50 of 3.5 nM and recombinant human ACC2 (hACC2) with an IC50 of 4.1 nM[1].

    Target: ACC




  • Previous:
  • Next:

  • Related Products

    
    WhatsApp Online Chat !