• Name: E-7046
  • Catalog No.: CPD1542
  • CAS No.: 1369489-71-3
  • Molecular Weight: 483.39
  • Chemical Formula: C22H18F5N3O4
  • For scientific research only, not for patients.

    Product Detail

    Product Tags

    Pack Size Availability Price (USD)
    50mg In stock 300
    100mg In stock 500
    1000mg In stock 1000

    Chemical Name:

    (S)-4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxamido)ethyl)benzoic acid

    SMILES Code: 


    InChi Code:


    InChi Key:



    E-7046, E7046, E 7046, 1369489-71-3

    Solubility: Soluble in DMSO

    Storage:  0 - 4°C for short term (days to weeks), or -20°C for long term (months).


    In the CT-26 tumor model, the E7046/RT combination causes the anti-tumor memory response of 9 animals. In the 4T1 model, the combination of E7046 and RT also produces significant better tumor growth inhibition activity compared with each treatment alone. The combination significantly improves survival by inhibiting the subsequent spontaneous lung metastasis of 4T1 tumors[1]. E7046 (150 mg/kg) inhibits the growth of multiple syngeneic tumor models. Blockade of EP4 signaling promotes anti-tumor DC differentiation and slows tumor growth in mice. E7046 treatment reduces the growth or even rejected established tumors in vivo in a manner dependent on both myeloid and CD8C T cells. Furthermore, co-administration of E7046 and E7777, an IL-2-diphtheria toxin fusion protein that preferentially kills Tregs, synergistically disrupts the myeloid and Treg immunosuppressive networks, resulting in effective and durable anti-tumor immune responses in mouse tumor models[2].

    Target: EP4

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