BGB-324; Bemcentinib; R428

BGB-324; Bemcentinib; R428
  • Name: BGB-324; Bemcentinib; R428
  • Catalog No.: CPDB1725
  • CAS No.: 1037624-75-1
  • Molecular Weight: 506.64
  • Chemical Formula: C30H34N8
  • For scientific research only, not for patients.

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    100mg In Stock 500
    500mg In Stock 800
    1g In Stock 1200
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    BGB-324, Bemcentinib, R428, BGB324, BGB 324, R-428, R 428, 1037624-75-1

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).


    BGB-324, also known as R428 or Bemcentinib, is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production.

    Target: AXL

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